Valacyclovir - An Overview
Valacyclovir is an antiviral drug used to treat and suppress infections caused by herpes simplex virus (HSV-1 and HSV-2) and varicella-zoster virus. People who need treatment for cold sores, genital herpes or shingles can connect with a medical provider through Push Health who can prescribe valacyclovir medication when appropriate to do so.
What Is Valacyclovir Used For?
Valacyclovir prescription medication, marketed under the brand name Valtrex, is an antiviral medication used in various situations:
- Genital herpes: Episodic treatment of outbreaks and daily suppressive therapy.
- Cold sores (herpes labialis):
- Shingles (herpes zoster): Acute treatment
- Chickenpox: Selected patients (e.g., adults or those at higher risk of complications).
- Transmission reduction: Daily valacyclovir is FDA-approved to help reduce the risk of transmitting genital herpes to uninfected partners.
Valacyclovir belongs to a class of drugs known as nucleoside analogue DNA polymerase inhibitors. After oral administration, valacyclovir is rapidly converted to acyclovir (Zovirax) which inhibits viral DNA replication. Valacyclovir has a higher oral bioavailability than acyclovir which allows for less frequent dosing. Valacyclovir is similar to the medication famciclovir (previously Famvir).
Valacyclovir - Dosage & Cost
Valacyclovir is often prescribed using several regimens which are sometimes customized to the needs of individual patients based on the judgment of the prescribing medical provider:
- Cold sores: 2 g every 12 hours for 1 day (two doses)
- Genital herpes - episodic: 500 mg or 1 g twice daily for 3-10 days (depending on initial vs recurrent episode)
- Genital herpes - daily suppression: 500 mg once daily (or 1 g once daily for very frequent outbreaks)
- Shingles: 1 g three times daily for 7 days
Dose adjustment is often needed in people with kidney impairment. Staying well hydrated is also important while taking valacyclovir prescription medication.
Can I Buy Valacyclovir Online?
Valacyclovir OTC (over-the-counter) is not available in the United States as valacyclovir is a prescription medication. Push Health can connect people who need a valacyclovir prescription with a medical provider who can, when appropriate, prescribe valacyclovir and send it to the pharmacy of the patient's choice.
Valacyclovir - Side Effects
Valacyclovir prescription medication can cause side effects such as headache, nausea and abdominal pain. These side effects are typically mild. Moe significant side effects include thrombotic thrombocytopenic purpura / hemolytic uremic syndrome (TTP/HUS), kidney failure, and adverse central nervous system events. Valacyclovir does not eliminate latent virus and transmission is always a consideration, especially during outbreaks. Dose adjustment is sometimes needed in the setting of kidney issues and adequate hydration is recommended while using the medication. People with a sensitivity to valacyclovir, acyclovir or similar antivirals in the past should not use the medication. Questions about side effects or other concerns should be discussed with one's medical provider.
How to Get a Valacyclovir Prescription with Push Health
- Complete a brief health intake. Describe your herpes symptom history, whether you need episodic treatment or daily suppression, current medications, and relevant medical history, including past kidney issues and prior allergies.
- Connect with a licensed medical provider. A provider will review your information and evaluate whether valacyclovir is appropriate and which dosing regimen - episodic or suppressive - fits your needs. Same-day consultations are available.
- Receive your prescription electronically. If approved, your provider will send a prescription to a pharmacy of your choice - no office visit required.
- Pick up your medication and start promptly. Generic valacyclovir is widely available at most pharmacies. Begin treatment as soon as possible after symptoms appear for best results.
No health insurance or subscription is required. Medical providers are available now.
More Valacyclovir Information
Last updated August 17, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.