Acyclovir - Summary

Acyclovir, sometimes marketed as Zovirax, is an antiviral medication used to treat and suppress infections caused by herpes simplex virus (HSV-1 and HSV-2) and varicella-zoster virus. Push Health can connect people who need treatment for genital herpes, cold sores, or shingles with a medical provider who can prescribe the medication to a local or delivery pharmacy when appropriate to do so.

What Is Acyclovir Used For?

Acyclovir belongs to a class of medications known as synthetic nucleoside analogues that work interferes with viral DNA replication. Related oral options include antiviral medications famciclovir (Famvir) and valacyclovir (Valtrex). Common uses:

Genital Herpes (HSV-2). Acyclovir is used for episodic treatment of outbreaks and daily suppressive therapy to reduce outbreak frequency and transmission risk.

Cold Sores (Oral Herpes / HSV-1). Acyclovir is used to treat cold sores and is most effective when started at the first sign of tingling or burning.

Shingles (Herpes Zoster). Acyclovir is ideally started within 48-72 hours of rash onset. It can help reduce the severity and duration of the episode and lower the risk of postherpetic neuralgia (persistent nerve pain).

Chickenpox (Varicella). Acyclovir is used in selected patients - particularly adults, adolescents, immunocompromised patients, and those with severe disease - to reduce the duration and severity of the illness.

Acyclovir vs. Valacyclovir - What Is the Difference?

Valacyclovir (Valtrex) is a prodrug that the body converts into acyclovir after it is absorbed. Both produce the same active drug but differ in convenience and cost.

	Acyclovir	Valacyclovir
Active compound	Acyclovir	Converted to acyclovir
Oral bioavailability	≈ 20%	≈ 55%
Cost	< 10 cents / tablet	15-30 cents / tablet

For most patients, valacyclovir's simpler dosing schedule is preferable, particularly when it is being used for daily suppressive therapy. Despite requiring more frequent dosing, acyclovir remains appropriate for patients where cost is a significant consideration. A licensed provider can advise on whether acyclovir or valacyclovir is most appropriate for a specific patient's indication, dosing preference, and budget.

Acyclovir - Dosage and Cost

Acyclovir medication is available in capsule, tablet, cream and ointment forms. The dose and treatment vary depending on the indication and the patient's health history but, frequently, the following regimens are used*:

• Genital herpes (episodic): 400 mg three times daily for 5-10 days or 800 mg twice daily for 5 days
• Genital herpes (daily suppression): 400 mg twice daily
• Shingles: 800 mg five times daily for 7-10 days (start within 72 hours of rash onset)
• Chickenpox in adults: 800 mg four times daily for 5 days

*Patients should discuss their situation with their medical provider to get the acyclovir treatment regimen that is appropriate for them.

Generic acyclovir 400 mg tablets are very affordable - typically under 10 cents per tablet at most pharmacies. A standard 5-day outbreak treatment course can cost under $5. Daily suppressive therapy costs approximately $6-$15 per month. Some insurance plans may cover some or all of the cost of acyclovir prescription medication. Prescription savings cards may also be available online for people who want to look for additional savings. Acyclovir should typically be stored at 15° C to 25° C.

Can I Buy Acyclovir Online?

Acyclovir is a prescription medication and acyclovir over the counter (OTC) is not available. Push Health can connect people who need an acyclovir prescription with a licensed medical provider who can prescribe the medication to the patient's pharmacy when appropriate to do so.

Acyclovir - Side Effects

Acyclovir prescription medication can cause side effects when used, including nausea, vomiting, fatigue, myalgia and headache. Anyone with a prior hypersensitivity to the medication or similar drugs should not use it. Dose adjustments sometimes need to be made for people with abnormal kidney function. Acyclovir does not eliminate latent virus so transmission is still possible, especially during outbreaks. Safe-sex practices and partner discussion remain important. Concerns about side effects related to the medication should be directed to one's pharmacist or medical provider.

How to Get an Acyclovir Prescription with Push Health

1. Complete a brief health intake. Describe your symptoms (e.g. outbreak location, timing), medical history, prior treatments, and current medications.
2. Connect with a licensed medical provider. A medical provider will review your information and determine whether acyclovir or another medication is appropriate for your situation. Same-day consultations are available.
3. Receive your prescription electronically. If prescribed, your provider will send a prescription to a pharmacy of your choice. No office visit required.
4. Pick up your medication. Generic acyclovir is available at most retail pharmacies and is inexpensive. Start your treatment as soon as possible after symptoms appear for best results.

No health insurance or subscription is required. Medical providers are available now.

More Acyclovir Information

• Acyclovir - Medline