Zepbound - Overview

Zepbound prescription medication is sometimes prescribed to people who need medical treatment for weight management. People who might need the medication can use Push Health to connect with a medical provider who can prescribe Zepbound injections and vials when appropriate to do so.

What Is Zepbound Used For?

Zepbound prescription medication contains the tirzepatide and is approved by the FDA for weight management (weight loss) in some adult patients. Zepbound, like Mounjaro, combines a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. Many patients experience reduced appetite and hunger, improved insulin sensitivity and glucagon levels, and better controlled blood glucose levels while using the medication in conjunction with diet and exercise. Zepbound is similar to Foundayo, Ozempic and Wegovy.

FDA-approved uses include:

• Chronic weight management in adults with BMI ≥ 30, or adults with a BMI ≥ 27 with at least one weight-related condition (e.g. hypertension, dyslipidemia, type 2 diabetes, cardiovascular disease, or obstructive sleep apnea)
• Moderate to severe obstructive sleep apnea (OSA) in adults with obesity

Zepbound is not a short-term diet shot. Stopping therapy is often associated with weight regain unless lifestyle changes are maintained.

Zepbound - Dosage and Cost

Zepbound is typically prescribed to be titrated over a period of time, depending on the patient's unique health needs and the judgment of the prescribing medical provider:

• Start at 2.5 mg once weekly. This is generally a starter dose and not intended as long-term maintenance.
• Increase by 2.5 mg increments. This is often done every 4 weeks as tolerated, depending on the response to the medication.
• Maintain the medication at 5 mg, 10 mg, or 15 mg once weekly. Other regimens might be used, depending on the situation

Zepbound is typically prescribed to be injected subcutaneously in the abdomen, thigh, or upper arm. Injection site rotation is recommended. Zepbound is available as prefilled pens and, in some channels, single-dose vials (vials require drawing up with a syringe).

Zepbound is available through Eli Lilly's Lilly Direct program (accessible through Push Health) with single dose vials ranging in price. In general, Zepbound typically starts at $299 per month through Lilly Direct and retail pharmacies. Manufacturer direct-to-patient programs and savings offers may lower cash prices for eligible patients. Insurance coverage varies.

Zepbound for Weight Loss

Zepbound was approved by the FDA for weight loss in November 2023. The SURMOUNT-1 study showed that overweight or obese patients demonstrated substantial weight reduction (5-20%) when using the medication compared to placebo. Weight reduction has also been seen in studies looking at type 2 diabetics specifically.

Participants in the SURMOUNT-3 trial demonstrated an additional 21.1% mean weight loss for a total mean weight loss of 26.6% from study entry over 84 weeks. Participants in the SURMOUNT-4 trial showed a total mean weight loss of 26.0% over 88 weeks. Another study showed that the active ingredient in Zepbound resulted in study participants losing an additional 18.4% of body weight compared to a gain in the placebo group over a 72 week period. Zepbound is also showing promise as a viable alternative to weight loss surgeries such as gastric bypass and sleeve gastrectomy surgeries.

Zepbound vs Mounjaro, Ozempic and Wegovy

Product	Ingredient	Indications	Receptor Targets
Zepbound	Tirzepatide	Weight Management, OSA	GIP + GLP-1
Mounjaro	Tirzepatide	Type 2 Diabetes	GIP + GLP-1
Ozempic	Semaglutide	Type 2 Diabetes, Selected CV risk reduction	GLP-1
Wegovy	Semaglutide	Weight Management, Selected CV risk reduction	GLP-1

Can I Buy Zepbound Online?

Zepbound medication requires a prescription to be dispensed by a pharmacy in the United States and is not available over the counter. People who might want a Zepbound prescription can use Push Health to connect with a medical provider who can prescribe the medication (injections and vials) to the pharmacy of the patient's choice when appropriate to do so.

Zepbound - Other Indications

Zepbound is the first medication approved by the FDA for obstructive sleep apnea. One study reported that the active ingredient in Zepbound injections might also have some effects on high blood pressure. Zepbound may also have a role in the treatment of fatty liver disease and lower the risk of death in some people with cardiovascular conditions. Zepbound might help reduce the risk of progression to type 2 diabetes in some patients.

Zepbound - Side Effects

Zepbound prescription medication can cause side effects when used. The most commonly reported adverse effects following Zepbound prescription injection use are gastrointestinal, including nausea, vomiting, diarrhea, abdominal pain, fatigue, reflux, constipation and injection-site reactions. Rotating the injection site will help minimize site reactions.

Zepbound medication should not be used by people with certain types of thyroid cancers or Multiple Endocrine Neoplasia syndrome type 2. Zepbound can cause pancreatitis, gallbladder problems and kidney problems. Zepbound can impact the absorption of other medications. Low blood sugar can occur when Zepbound medication is combined with insulin or sulfonylureas.

Zepbound prescription medication should generally not be used by pregnant or breastfeeding women. Withdrawal of the use of Zepbound's active ingredient has been associated with regaining of lost weight. People with a hypersensitivity to Zepbound or similar medications should avoid using the medication. Zepbound and alcohol should not be used together. Discuss any concerns about using the medication with your medical provider.

How to Get a Zepbound Prescription with Push Health

1. Complete a brief health intake. Share your weight and BMI information, weight-related conditions (including sleep apnea if relevant), current medications, and any history of pancreatitis, gallbladder disease, or thyroid cancer/MEN2.
2. Connect with a licensed medical provider. A medical provider will review your information and confirm appropriateness. Same-day consultations available.
3. Receive your prescription electronically. If approved, your prescription will be sent to the pharmacy of your choice. No office visit required.
4. Start treatment and follow the plan. Inject weekly as directed and maintain the recommended diet and activity. Escalate only as instructed and discuss any side effects with your medical provider.

No health insurance or subscription is required for the consultation itself. Medical providers are available now.

More Zepbound Information

• Zepbound - FDA